Whole Mouse Brain Atlas Publication Package Highlights (Feb 1, 2024)

The millions to billions of cells that comprise mammalian brains are organized into many highly specialized cell types. Previous studies have demonstrated that known and novel cell types can be identified by their single-cell gene expression profiles. However, the actual number of cell types in the brain and the degree of diversity among these cell types has been unknown.

This webinar presents a new collection of studies from the BRAIN Initiative Cell Atlas Network (biccn.org) and published in Nature on Dec 14, 2023, that report the first complete cell type atlas of a mammalian brain, with over 30 million cells profiled from the adult mouse brain using a combination of single-cell transcriptomic, epigenomic, and spatial transcriptomic approaches, identifying over 5,300 cell types in the entire mouse brain.

These studies uncover multitudes of organizing principles of the extraordinary cell type diversity across the brain. This collective body of work represents a landmark achievement that will have far-reaching impact on understanding cell type-based brain circuit function across the neuroscience field.

More about the collection of studies, published in Nature on December 13, 2023: https://www.biccn.org/science/whole-mouse-brain

Speakers:
1:21 Overview - Hongkui Zeng https://www.biccn.org/science/whole-mouse-brain

6:20 A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain - Zizhen Yao https://www.nature.com/articles/s41586-023-06812-z

17:38 Molecularly defined and spatially resolved cell atlas of whole mouse brain - Xingjie Pan https://www.nature.com/articles/s41586-023-06808-9

28:52 The molecular cytoarchitecture of the adult mouse brain - Jonah Langlieb https://www.nature.com/articles/s41586-023-06818-7

38:40 Single-cell DNA methylome and 3D multi-omic atlas of the adult mouse brain - Hanqing Liu https://www.nature.com/articles/s41586-023-06805-y

51:59 Single-cell analysis of chromatin accessibility in adult mouse brain - Songpeng Zu https://www.nature.com/articles/s41586-023-06824-9

1:00:25 Brain-wide correspondence of neuronal epigenomics and distant projections - Jingtian Zhou https://www.nature.com/articles/s41586-023-06823-w

1:11:01 A transcriptomic taxonomy of mouse brain-wide spinal projecting neurons - Carla Winter https://www.nature.com/articles/s41586-023-06817-8

1:22:10 Spatial atlas of the mouse central nervous system at molecular resolution - Hailing Shi https://www.nature.com/articles/s41586-023-06569-5

1:32:49 Conserved and divergent gene regulatory programs of the mammalian neocortex - Ethan Armand https://www.nature.com/articles/s41586-023-06819-6

1:43:34 Evolution of neuronal cell classes and types in the vertebrate retina - Karthik Shekhar https://www.nature.com/articles/s41586-023-06638-9

1:54:21 Q&A. Moderator: Yasmeen Hussain, Allen Institute for Brain Science

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The research and webinar presented was funded by grants from the National Institutes of Health’s Brain Research Through Advancing Innovative Neurotechnologies® Initiative (The BRAIN Initiative). The publications were supported by and coordinated through the BICCN (biccn.org) and BICAN (brain-bican.org).

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##BICCN

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