Daily Naltrexone vs The Sinclair Method: What's the Difference? Dr. Volpicelli Answers

Targeted Naltrexone combined with a daily low dose of Ketamine(80MG) has been incredibly effective for me. I feel liberated at last.

Thank you for the information

Its not always true. i take 50mg of naltrexone and still feel energized after a few drinks and want and do keep going

Daily AM at about 10 flattens me out and keeps me needing to rush home and skipping life to make the appointment to get the buzz as I feel flat and ok during the day, that super strong craving is dulled out during the day, then I find if I do want to drink, I get a controlled glow still and I can - want or just stop at about 2-3 strong drinks over about 45 minutes, with a nice glow, instead of no pill = 6-8 drinks and no memory of the second half of the session. I did do target on the first night, 1 hour, and yes, it killed the whole session after about 1.25 drinks as there was NO glow so that works as a back up tool like me - if you wake up in the middle of night even after an afternoon session and want to "put one on"....take the pill and try to wait, and it will let you just go back to bed. its stopped me from doing a "double" session in th 24 hours!

I took my first naltrexone yesterday. Usually a bottle of wine a night, or more, and i only had 1 & 1/2 glasses. Normally when I cut back I replace with food but I had no desire to overeat. I feel hopeful this will work for me.

Very well explained by Dr. Volpicelli. Even though I have been a pretty heavy daily user for 30 years, I think I am more of a person who can use the Sinclair Method of targeted Naltrexone use. I guess I will find out, I am on my second day of treatment.

What do you consider long history? So many accelerated and or became drinkers during Covid.

What about Native,Americans who have such a heightened sensitity to alcohol which was really introduced to them wherever they were colonised? Have you looked into this with Native Communities, which are and have been devastated by alcohol?

Thank you for the information, I was really questioning why my provider wanted me to do daily naltrexone vs the sinclair method. This really helped clarify why the daily naltrexone is the best option for me, especially starting out

No wonder. I am 13 months in and I am not a good candidate for targeted naltrexone. I recently started taking it every day at lunch. I will see how that works for me