Difference between flocculated and deflocculated suspension || Physical pharmaceutics

Difference between flocculated and deflocculated suspension || Physical pharmaceutics

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In this video we discussed about flocculated and deflocculated suspension ....👆👆📜📜

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👉👉 Some basic discription about topic...👈👈

What is Flocculated suspension?
Answer

A flocculated suspension is a type of suspension where the particles have aggregated into loose clusters or flocs. This is often done intentionally in pharmaceutical and industrial processes to enhance the stability and ease of handling of the suspension. Here are some key points about flocculated suspensions:
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Particle Aggregation:
In a flocculated suspension, particles come together to form flocs or loose aggregates. This reduces the surface area exposed to the liquid, decreasing the tendency for particles to settle out rapidly.
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Stability:
Flocculation helps stabilize the suspension by preventing the formation of a hard sediment layer. The flocs are easily redispersed upon shaking, maintaining the homogeneity of the suspension.
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Sedimentation:
Although flocculated particles tend to settle faster than deflocculated ones due to their larger size, the sediment formed is loose and can be easily redispersed.
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Agents Used:
Flocculating agents, such as electrolytes, polymers, or surfactants, are often added to induce flocculation. These agents neutralize the surface charges on particles, allowing them to come together and form flocs.
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Applications:
Flocculated suspensions are commonly used in pharmaceuticals (e.g., oral suspensions), water treatment, and various industrial processes where maintaining a uniform suspension is critical.
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What is deflocculated suspension?
Answer -
A deflocculated suspension is one where the individual particles remain dispersed and do not form flocs or aggregates. Here are some key characteristics and aspects of deflocculated suspensions:
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Particle Dispersion:
In a deflocculated suspension, the particles are uniformly dispersed throughout the liquid, and each particle exists separately without forming clusters.
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Stability: 👇
Deflocculated suspensions are less stable compared to flocculated ones. Over time, the particles tend to settle slowly and form a compact sediment at the bottom, which is often difficult to redisperse.
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Sedimentation: 👇
The particles in a deflocculated suspension settle very slowly because they remain as individual units. However, the sediment formed is typically hard and compact, making it challenging to redisperse upon shaking.
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Zeta Potential:👇
Deflocculated suspensions usually have a high zeta potential (a measure of the magnitude of the electrostatic repulsion between particles). This high zeta potential keeps the particles separated and prevents them from aggregating.
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Agents Used: 👇
To maintain deflocculation, dispersing agents or deflocculants are used. These agents increase the repulsive forces between particles, helping to keep them apart.
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Applications:👇👇
Deflocculated suspensions are used in applications where a very fine and uniform distribution of particles is needed, such as in paints, inks, and certain pharmaceutical preparations.

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Тэги:

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